Clinical significance of serum levels of growth factors in different kinds of inflammatory response
10.3760/cma.j.issn.1008-6315.2009.11.038
- VernacularTitle:不同类型炎症中生长因子水平差异及其意义
- Author:
Xiuhua DAI
;
Baochun ZHAO
;
Ruiying CHEN
;
Suxiang LI
;
Yuemin BAI
;
Jin MENG
- Publication Type:Journal Article
- Keywords:
Platelet-derived growth factor;
Vascular endothelial growth factor;
Infection;
Autoimmunity
- From:
Clinical Medicine of China
2009;25(11):1215-1217
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of platelet-derived growth factor(PDGF) and vascular endo-thelial growth factor(VEGF) in infectious and autoimmunity diseaases. Methods The growth factors were measured by ELISA in 149 patients for seven times in different periods,and the levels and duration were compared. Results PDGF was (6.32±2.54) μg/ml and (2.57±1.65) μg/ml (P<0.05), and VEGF was (179.5±53.30) ng/ml and (221.4±70.04) ng/ml(P<0.05) in the two groups before treatment;There was statistical significance in dif-ferent time points between groups and within groups for PDGF(P<0.05) and significant difference for time chan-ging to the peak and changed duration between two groups for VEGF(P<0.05). For the two groups,the peak time of PDGF were (2.6±1.1) and (5.4±3.3) days;The peak time of VEGF were (2.4±0.7) and (7.2±3.3) days respectively(P<0.05 for each). However in the two groups, the change duration were (6.7±3.1) and (15.4±6.1) days for PDGF and (8.1±3.4) and (16.7±7.2) days for VEGF (P<0.05 for each). Conclu-sions There is significant difference for serum levels of PDGF and VEGF and the level change duration as well in the two groups, which maybe correlated with inflammatory nature and outcome.
