Clinical effect of combination of clopidogrel and simvastatin on coronary heart disease complicated with transient ischemic attack
10.3760/cma.j.issn.1008-6315.2009.11.011
- VernacularTitle:氯吡格雷联合辛伐他汀治疗冠心病合并短暂脑缺血发作临床疗效观察
- Author:
Hong LI
;
Shilong JIA
;
Xiancai SU
- Publication Type:Journal Article
- Keywords:
Clopidogrel;
Simvastatin;
Coronary artery disease;
Transient isehemic attack
- From:
Clinical Medicine of China
2009;25(11):1149-1151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of combination of clopidogrel and simvastatin on coro-nary heart disease and transient ischemic attack(TIA). Methods 76 patients with coronary heart disease and TIA were randomly divided into test group (n=40) and control group (n=36). The control group was treated with en-teric-coated aspirin 50 mg×2 every night after supper, and the test group was treated with clopidogrel 25 mg×2 and simvastatin 10 mg×2 every night before sleep. Liver and kidney function, blood coagulation function and blood lipids were measured before treatment and after. 1 year followed-up. Results The effective rate was 95.0% (38/40) in test group and 55.5% (20/36) in control group(χ2=6.45,P<0.01). LDL-C was (3.18±1.24) mmol/L and (2.60±1.03)mmol/L(t=2.67,P<0.01),TC was(5.18±1.24) mmol/L and (4.02±2.18) mmol/L(t= 4.91, P<0.01),TG was (1.50±1.02) mmol/L and (1.30±1.03) mmol/L(t=1.02, P>0.05), respectively in test group before and after treatment. However, there was no statistical difference in LDL-C, TC and TG (t=0.17, 0.00,0.52,0.57,P>0.05 for each) in control group. The two groups showed no difference after treatment (t= 1.51,2.55,0.57, P>0.05 for each). Conclusions Glopidogrel combined with simvastatin capsules is safe in pre-vention of TIA attack.
