Progress in genetic models associated with Parkinson's disease
10.3760/cma.j.issn.1673-4181.2009.05.015
- VernacularTitle:帕金森病相关基因模型的研究进展
- Author:
Weixiong ZHANG
;
Yuefei SHEN
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Gene;
Genetic models
- From:
International Journal of Biomedical Engineering
2009;32(5):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD) is a kind of degenerative disease caused by both genetic and environ-mental factors. Concerning these two factors, various animal models for parkinson's disease were made for the study. Transgenic animal models were made by the method of microinjection, electronic perforation, particle bom-bardment, virus vector transfection and so on, which can express exogenous target gene. These models imitated the process of Parkinson's desease induced by virulence gene and provided a powerful tool for investigation on e-tiopathogenesis, gene therapy and medical intervention. In this article, we reviewed the progress of genetic models associated with PD and theirs contribution to PD research.
