Expressions and clinical value of serum SGF, TSGF and CEA in NSCLC patients
10.3760/cma.j.issn.1008-6706.2009.10.009
- VernacularTitle:非小细胞肺癌血清硫酸粘多糖片段、恶性肿瘤相关物质和癌胚抗原的表达及意义
- Author:
Chengde LI
;
Nanyang LI
;
Xueji SHEN
;
Haizhu LI
;
Lihong LIANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-Small-Cell Lung;
Sulfate glycosaminoglycan fragments;
Antigens,tumor-associated,carcinoembryomic antigen;
Carcinoembryonic antigen
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(10):1745-1746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a serological diagnostic method about NSCLC by investigating the expres-sion of 3 tumor markers of the sulfate glycosaminoglyean fragments(SGF), TSGF and CEA in NSCLC patients' serum. Methods To assay the level of SGF,TSGF and CEA in 50 NSCLC patients with latex particleagglutiation test,colori-metry of biochemistry and CLIA, respectively. Compared the clinical value of different examination combination way in NSCLC diagnosis value. Results There was high difference value between the Ⅰ - Ⅱ stage and the Ⅲ time,the Ⅲ time and the Ⅳ time about the level of SGF(P <0.05) in NSCLC patients. The specificity between SGF,TSGF and CEA each single item and the SGF and TSGF combination examination were not significant(P > 0.05). The semitivity between the SGF and TSGF combination and the SGF,TSGF and CEA combination was not significant(P >0.05), its specificity had significant difference(P <0.05). Conclusions There are higher expression about the 3 tumor mark-ers in NSCLC patients' serum. In the different combination examination, SGF and TSGF combined has great clinical value than other combinations to diagnosis NSCLC.
