Clinical significance of sICAM-1 and IL-1β in pregnant women with chorioamnionitis

VernacularTitle:可溶性细胞间黏附分子-1、白介素-1β与绒毛膜羊膜炎的关系
Author: Yizhe CHEN ; Jiayin ZHENG
Publication Type:Journal Article
Keywords: Chorioamnionitis; Vascular cell adhesion molecule-1; Interleukin-1 beta
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(10):1731-1733
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance of soluble intercellular adhesion molecule-1 (sICAM-1) and interleukin-1β(IL-1β) in pregnant women with chorioamnionitis. Methods The levels of sICAM-1, IL-1β,CRP and WBC were detected by enzyme linked immunosorbent assay in maternal serum of 56 pregnant women with PPROM and 38 pregnant women with PROM. Every embryolemma was histopathologically confirmed after deliver-y. Results Chorioamnionitis in PPROM was more than that in PROM of full term(P<0.05). The serum levels of sI-CAM-1, IL-1β, CRP and WBC in chorioamnionitis in pregnant women were higher than those in non-chorioamnionitis (P <0.05). The serum levels of sICAM-1 was more sensitive and specific than those of CRP and WBC. The serum levels of IL-1β was more sensitive than those of CRP and WBC, but their specificity was similar. Conclusion The levels of sICAM-1 and IL-1β in maternal serum are good clinical biological markers for predicting chorioamnionitis in pregnant women.