Role of SDF-1/CXR4 axis in treatment of cerebral ischemia with endothelial progenitor cells
10.3760/cma.j.issn.1673-4165.2009.10.015
- VernacularTitle:SDF-1/CXCR4轴在内皮祖细胞治疗脑缺血中的作用
- Author:
Shanshan ZHANG
;
Yong LUO
- Publication Type:Journal Article
- Keywords:
chemokine CXCL12;
receptors,CXCR4;
endothelial cells;
stem cells;
cerebral ischemia
- From:
International Journal of Cerebrovascular Diseases
2009;17(10):792-796
- CountryChina
- Language:Chinese
-
Abstract:
Studies in recent years have demonstrated that stromal cell-derived factor-1 SDF-1/CXCR4 axis plays an important role in the process of angiogenesis. The expression of SDF-1 in ischemic tissue increases during cerebral ischemia. It binds to CXCR4 receptor on the surface of endothelial progenitor cells EPCs, and thus promotes bone marrow-derived EPC mobilization, proliferation, and migration to the ischemic areas and homing. EPCs differentiate into mature endothelial cells in the ischemic region, promote the formation of new blood vessels, and thus irrlprove the blood supply to ischemic tissue. This article reviews the effect of SDF-1/CXCR4 axis in the treatment of cerebral ischemia with EPCs.
