High mobility group box 1 and central nervous system disease
10.3760/cma.j.issn.1673-4165.2009.10.016
- VernacularTitle:高迁移率族蛋白B1与中枢神经系统疾病
- Author:
Lina WANG
;
Lingling LIU
;
Lili CUI
;
Rui YANG
;
Min LI
;
Wei DU
;
Xiangjian ZHANO
- Publication Type:Journal Article
- Keywords:
HMGB1 protein;
inflammation;
stroke;
Alzhcimer's disease
- From:
International Journal of Cerebrovascular Diseases
2009;17(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1 (HMGB 1 ) is a family member of the high mobility group. HMGB1 binds to cell surface specific receptor-receptor for advanced glycation end products (RAGE) and toll-like receptor 2 (TLR2), and thus it exhibits extensive biological activities. HMGB1 participates in pathophysiological processes including inflammatory response and regulation of blood-brain barrier permeability in central nervous system, arid it is closely correlated with the diseases such as ischemia stroke, Alzheimer's disease and gliocytoma.
