The expression of JNK and MRP1 in colorectal carcinoma
10.3760/cma.j.issn.1008-6706.2009.10.006
- VernacularTitle:c-jun氨基末端激酶与多药耐药相关蛋白1在结直肠癌组织中的表达
- Author:
Ruoming WANG
;
Zhen YANG
;
Guozhen SENG
- Publication Type:Journal Article
- Keywords:
JNK mitogen-activated protein kinases;
Multidrug resistance-associated proteins;
Colorectal neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(10):1739-1740
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the chnicopathogenical significance of c-jun N-terminal kinase(JNK) and multidrug resistance associated protein 1 (MRP1) expression in colorectal cancer. Methods The expression of JNK and MRP1 was detected in a tissue microarray containing 72 spots of colorectal cancer tissue and 40 spots of nor-mal colorectal tissue by immunohistochemisty. Results The positive expression rate of JNK and MRP1 expression was 47.22% and 51.39% respectively in colorectal cancer,significantly higher than that in normal colon tissue. JNK protein expression was not closely related to gender, age, tumor size and location (P>0.05), but closely related to tumor differentiation,lymph node metastasis,distsnt metastasis and Dukes staging (P<0.05). MRP1 protein expres-sion was not closely related to gender,age,tumor size,location and tumor differentiation(P> 0.05), but closely relat-ed to lymph node metastasis, distant metastasis, Dukes staging (P<0.05). Conclusions The JNK expression in cancer is corrlated with maligant biological behavior and may be involved in the chemotherapeutic resistance by upreg-ulating the expression of MRP1.
