Study on the Relationship Between IL-6 and Newly Diagnosed type 2 Diabetes Mellitus with Dampness-Heat Encumbering the Spleen Syndrome
10.3760/cma.j.issn.1673-4246.2009.06.014
- VernacularTitle:新诊断2型糖尿病湿热困脾证与IL-6的关系研究
- Author:
Yangang SHI
;
Tianshu GAO
;
Peng CUI
;
Jingjing LI
;
Yao MA
;
Mingzhe LI
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
IL-6;
Dampness-Heat Encumbering the Spleen
- From:
International Journal of Traditional Chinese Medicine
2009;31(6):512-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between interleukin-6(IL-6) and the newly diagnosed type 2 diabetes mellitus with Dampness-Heat Encumbering the Spleen syndrome and the relationship between overweight and IL-6. Methods The plasma levels of IL-6 were detected by radio immunoassay in 40 patients with the newly diagnosed type 2 diabetes mellitus (Dampness-Heat Encumbering the Spleen syndrome 10 cases and the deficiency of Qi and Yin syndrome 10 cases)and 10 healthy adults. The changes of body mass index (BMI) and waist-hip ratio (WHR) were observed and analyzed in each group. Results The level of IL-6 in blood plasma of patients with the newly diagnosed type 2 diabetes mellitus were obviously higher than that in normal group (P< 0.01); IL-6 level in patients with Dampness-Heat Encumbering the Spleen syndrome and overweight were obviously higher than those with the deficiency of Qi and Yin syndrome (P< 0.01). Conclusion Interaction between the high level of cytokines and (or) overweight may affect the normal immune function, and promote the development of diabetes, especially in patients with Dampness-Heat Encumbering the Spleen syndrome. The high level of IL-6 may indicate the large possibility of future T2DM and can be considered as a new diagnosis of T2DM syndrome differentiation.
