Toll-like receptor and cancer of digestive system
10.3760/cma.j.issn.1673-4203.2009.11.017
- VernacularTitle:Toll样受体与消化系统肿瘤的研究进展
- Author:
Qian QIAO
;
Chengyu GU
;
Bing CAI
- Publication Type:Journal Article
- Keywords:
Toll-like receptor;
cancer of digestive system;
immunotherapy
- From:
International Journal of Surgery
2009;36(11):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Cancer of digestive system is one of the most common worldwidely cancers and seriously threats to human health. However its etiology and pathogenesis are still not clear. Toll-like receptor (TLR), a newly discovered transmembrane receptor, plays an important role in innate immunity. Recent researches suggested that TLRs had extensive relationship with inflammation, autoimmune diseases and cancer. A large number of researches indicated that TLRs not only participated in the occurrence, development and immune escape of cancer, but also acted in immunotherapy in digestive system. Further investigation of TLRs may re-veal the effects of TLRs in the development of malignant tumors of digestive system, moreover may find new therputic target for the treatment of cancers. We reviewed the relationship between TLRs and cancers of di-gestive system.
