The role of nerve growth factor in the pathogenesis of diabetic neuropathy

VernacularTitle:血清神经生长因子在糖尿病性周围神经病变发病中的作用
Author: Chongjuan WEI ; Yan CHENG ; Xiaodong KONG ; Hao LIANG ; Ying CHEN
Publication Type:Journal Article
Keywords: Diabetes mellitus; Peripheral nervous system diseases; Nerve growth factor; Neural conduction
From: Chinese Journal of Geriatrics 2009;28(11):887-889
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of nerve growth factor (NGF) in the pathogenesis of diabetic neuropathy (DNP) and the correlation of NGF level with,sensory nerve conduction velocity (SNCV) and duration of DNP.MethodsThe 41 patients with DNP,35 diabetics without DNP and 33 healthy controls were enrolled.And the serum level of NGF was measured with ELISA,the SNCV of left medial nerve,ulnar nerve,peroneal nerve and tibial nerve were measured too. Then the correlation analysis was completed. ResultsThe serum level of NGF was significantly lower in DNP patients [(665.18±188.32) ng/L] than in healthy controls [(976.44±159.07)ng/L] and in diabetics without DNP [(943.32±167.33) ng/L,F=9.316,P<0.001].The NGF level of DNP patients was positively correlated with SNCV of left medial nerve (r=0.810,P<0.001 ),left peroneal nerve (r=0.760,P<0.001) and duration of DNP (r=0.542,P<0.001).Conclusions The serum level of NGF is lower in DNP patients than in healthy controls.The decrease of the production of NGF may play a role in the pathogenesis of DNP.