Cognitive impairment caused by cerebral small-vessel disease Magnetic resonance spectroscopy and diffusion tensor imaging
10.3760/cma.j.issn.1673-4165.2009.10.011
- VernacularTitle:脑小血管病引起的认知障碍磁共振波谱和弥散张量成像
- Author:
Lian HUANG
;
Anding XU
;
Xueying LING
;
Xuewen SONG
- Publication Type:Journal Article
- Keywords:
cerebrovascular disorders;
cognitive disorders;
magnetic resonance spectroscopy;
diffusion magnetic
- From:
International Journal of Cerebrovascular Diseases
2009;17(10):774-777
- CountryChina
- Language:Chinese
-
Abstract:
The manifestation of clinical symptoms of cerebral small-vessel disease (SVD) is cognitive disorders. Its pathological changes are manifested as leukoaraiosis and/or lacunar infarction. However, it is not clear whether cognitive disorders caused by SVD is correlated with the severity of white matter damage. Magnetic resonance spectroscopy analysis can noninvasively detect metabolite concentrations of brain tissue in vivo and directly reflect cerebral metabolism; Diffusion-tensor imaging is a novel noninvasive technique for specific observation of white matter through different parameters such as mean diffusivity and anisotropy for quantitative evaluation of the abnormalities of fine structure of white matter. The combination of magnetic resonance spectroscopy analysis and diffusion-tensor imaging may more sensitively reveal the severity of white matter damage, and provide a research tool for cognitive disorders caused by SVD.resonance imaging
