The common targets of preconditioning and postconditioning in the treatment of cerebral ischemia
10.3760/cma.j.issn.1673-4165.2009.10.014
- VernacularTitle:预适应和后适应在脑缺血治疗中的共同靶点
- Author:
Yu WANG
;
Yumin LUO
;
Yuhong ZHU
;
Xunming JI
- Publication Type:Journal Article
- Keywords:
brain ischemia;
ischemic preconditioning;
reperfusion injury
- From:
International Journal of Cerebrovascular Diseases
2009;17(10):787-791
- CountryChina
- Language:Chinese
-
Abstract:
As an endogenous organism protective measure in vivo, preconditioning/ postconditioning in the process of ischemia/reperfusion may play common protective mechanisms, such as reducing the generation of oxygen free radicals, activating adenosine receptor, increasing endogenous nitric oxide and heat shock protein, inhibiting immune inflammatory response and neuronal apoptosis, activating intracellular signal transduction pathways, opening mitochondrial ATP-sensitive potassium channels, as veil as closing mitochondrial permeability transition pores. Investigating the common target of these mechanisms may provide a new theoretical basis for developing new drugs and reducing ischemia/reperfusion injury.
