VEGF and Notch pathways in tumor angiogenesis
10.3760/cma.j.jssn.1673-422X.2009.11.006
- VernacularTitle:血管内皮生长因子和Notch信号通路与肿瘤血管生成
- Author:
Yayun QIAN
- Publication Type:Journal Article
- Keywords:
Signal transduction;
Neoplasms;
Neovascularization,pathologic
- From:
Journal of International Oncology
2009;36(11):818-821
- CountryChina
- Language:Chinese
-
Abstract:
VEGF and Notch signaling pathways are important mechanisms in regulation of embryonic vascular development and tumor angiogenesis.Blockade of the VEGF pathway effectively inhibits tumor anglo- genesis and growth.Recent findings indicate that Notch signaling decreases angiogenesis by suppressing endo-thelial tip cell formation.Combination therapy by blocking Notch and VEGF pathways synergistically inhibits tumor growth in preclinical models.Thus,targeting VEGF and Notch pathways may lead to new therapies for clinical application.
