Microvessel density and expression of VEGF and AR in the prostates of men who received re-operation after TURP for benign prostatic hyperplasia

VernacularTitle:再次TURP患者前列腺组织微血管密度、血管内皮生长因子和雄激素受体的表达及意义
Author: Tongyu GUAN ; Qingzeng SUN ; Jingguang QI ; Jingyi CAO ; Gang WU ; Ning YANG ; Zhengyu CHENG ; Jie LIANG ; Qian WANG
Publication Type:Journal Article
Keywords: Transurethtal resection; prostate; Reoperation; Microvessel density; Vascular endothelial growth factor; Androgen receptor
From: Chinese Journal of Urology 2009;30(12):845-847
CountryChina
Language:Chinese
Abstract: Objective To discuss microvessel density (MVD) and expression of vascular endothelial growth factor(VEGF), androgen receptor(AR) in the prostates of men who received re-operation after TURP. Methods Fifty cases were performed re-TURP (re-TURP group) and the remaining 50 cases served as controls. 150 specimens were collected. Sections were stained for CD34 and VEGF, AR by immuno-histo-chemistry(S-P). Statistical analysis of the results was performed using t-test or Pearson Chi-Square test Results The expression of VEGF, AR and MVD were significantly higher in the re-TURP group compared to controls(P<0. 05),but in re-TURP group, difference in VEGF and AR expression as well as MVD were not found to be significantly different between the first and the second TURP(P>0.05). Conclusion Over expression of VEGF and AR as well as high MVD in prostatic tissue might play an important role in the pathological process of BPH after TURP.