Current research on breast cancer stem cells
10.3760/cma.j.issa.1673-422X.2009.11.016
- VernacularTitle:乳腺癌干细胞研究现状
- Author:
Xinrong WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Tumor stem cells
- From:
Journal of International Oncology
2009;36(11):846-850
- CountryChina
- Language:Chinese
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Abstract:
Tumor may generate from tumor stem cell and the microenvironment,and cancer stem cells are derived from the mutation of normal stem cells according to cancer stem cells hypothesis. Breast cancer stem cells are the first identified cancer stem cells in solid tumor. Breast cancer stem cells have been isolated successfully by many kinds of strategies, and their biological behaviors are gradually studied deeply. Self-renewal and differentiation of breast cancer stem cells are regulated by microenviroment and many signaling pathways. Therapy targeting breast cancer stem cells is gradually becoming the focus of tumor targeted therapy study.
