The clinical significance of urinary vascular endothelial growth factor measurement in patients with bladder cancer
10.3760/cma.j.issn.1673-4904.2009.32.002
- VernacularTitle:膀胱癌患者尿液血管内皮生长因子水平检测的临床意义
- Author:
Rongjiang WANG
;
Qilin SHI
;
Sihai SHAO
;
Hui LI
;
Xiaonong CHEN
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Vascular endothelial growth factor A;
Urine
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(32):4-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of urinary vascular endothelial growth factor (VEGF) and occurrence and invasiveness of bladder cancer. Method The expression of urinary VEGF in 48 patients with bladder cancer (bladder cancer group) and 45 normal cases (control group) were examined by ELISA immunohistochemical staining. Results VEGF levels in urine in bladder cancer group [(174.77±83.41) μg/L] were higher statistically than those in control group [(63.53 ±22.62) μg/L] (P < 0.01), and related to the staging and grading of tumors. VEGF levels were significant higher in invasive lesions [(223.00 ± 83.13) μg/L] than those in superficial ones [(130.40 ± 54.86) μg/L] (P < 0.01). VEGF levels of G3 [(259.23 ± 75.82) μg/L] were significant higher compared with G1 [(138.00± 85.60) μ g/L] and G2 [(146.22 ±47.53) μ g/L] (P < 0.01). Conclusion The concentration of urinary VEGF relates to the clinical staging and pathological grading, and it is a labeling index of the biological behavior of bladder cancer.
