Influence of body mass index on serum prostate-specific antigen in male younger than 50 years
10.3760/cma.j.issn.1000-6702.2009.12.024
- VernacularTitle:50岁以下男性年龄及体质量指数对血清前列腺特异抗原的影响
- Author:
Ming LIU
;
Ling ZHU
;
Gang WAN
;
Xin CHEN
;
Hong MA
;
Lanjun MA
;
Jie PAN
;
Weiwei JIANG
;
Jianye WANG
- Publication Type:Journal Article
- Keywords:
Prostate-specific antigen;
Body mass index
- From:
Chinese Journal of Urology
2009;30(12):852-855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the correlation of age and BMI with prostate-specific antigen (PSA)in male younger than 50 years of age. Methods The routine health examination data of 6808 males, younger than 50 years of age, were collected and reviewed. The height and weight were measured, so as to calculate the body mass index (BMI). Serum PSA was also examined. Eligible men were classified into age groups spanning 10 years. BMI was categorized as normal (BMI 18. 5 - 22. 9) , overweight (BMI 23. 0-24. 9), obese (BMI 25. 0 - 29. 9) , and very obese (BMI≥30. 0) according to the re-defined World Health Organization criterion for the Asia Pacific Region. PSA levels were stratified by age and BMI category. Results The mean age was (39. 2±7. 0)years, mean BMI (25. 6± 4. 7)kg/m~2 and mean PSA (0. 89±0. 56)ng/ml for the whole population. The PSA level in 10 - 19 age group was significantly lower than the other three groups (P<0. 01) and no significant difference was found among the other three groups. The BMI had negative correlated with PSA even when comparing in sub-age groups, except the 10-19 age group. Spearman analysis also found PSA had significant positive correlation with age and negative correlation with BMI. Conclusions Serum PSA level changes significantly with age in adolescence whereas quite slowly between 20-50 years of age. BMI has negative influence on PSA in male younger than 50 years of age.
