Research progression of microenviroment hypoxia influencing DNA damage-repair in tumour cells
10.3760/cma.j.jssn.1673-422X.2009.11.004
- VernacularTitle:微环境乏氧对肿瘤细胞DNA损伤修复的影响
- Author:
Liumei TONG
;
Libo FENG
;
Xueguan LU
- Publication Type:Journal Article
- Keywords:
Cell hypoxia;
DNA mismatch repair;
Neoplasms
- From:
Journal of International Oncology
2009;36(11):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Microenviroment hypoxia is one of the common phenomenon in cancer,studies have indiacat-ed that hypoxia induces genetic instability via activating many DNA danlage-repair signal pathways,which asso-ciates with tumor invasion and resistance and chemi-radiotherapy resistivity.Here,we overview three main DNA damage-repair pathways:mismatch repair,homologous recombination and non-homologous end joining,and how hypoxia influences their mechanisms.
