CD4~+T lymphocytes and tumor immunity
10.3760/cma.j.issn.1673-422X.2009.11.007
- VernacularTitle:CD4~+T 细胞与肿瘤免疫
- Author:
Meixiu ZENG
- Publication Type:Journal Article
- Keywords:
CD4-positive T-lymphoeytes;
Tumor immunity;
Immunotherapy:Cancer vaccines
- From:
Journal of International Oncology
2009;36(11):821-824
- CountryChina
- Language:Chinese
-
Abstract:
CD4~+T helper cells not only activate CD8~+T cells,but also play a pivotal role in the gener- ation and maintenance of memorial cytotoxic T lymphocytes(CTL).In addition, it is shown that CD4~+T cells have direct anti-tumor function.However,CD4~+ CD25~+ regulatory T cells(Tregs) negatively control immune re-sponse,and play an important role in immunosuppression and immune escape, it is considered as a key reason for ineffective immunotherapy.In recent years,there is great progress in cancer immunotherapy,and relevant cancer vaccines have attracted a wide spread attention.
