Advance in research of CDX2 and CDH17 in gastric cancer
10.3760/cma.j.issn.1673-4203.2009.12.016
- VernacularTitle:CDX2与CDH17在胃癌中的研究进展
- Author:
Hailin XI
;
Jianhua NIU
- Publication Type:Journal Article
- Keywords:
CDX2;
CDHI7;
gastric cancer
- From:
International Journal of Surgery
2009;36(12):831-834
- CountryChina
- Language:Chinese
-
Abstract:
Caudal-related homeobox transcription factor CDX2 is a specific nuclear transcription factor. It seems to play a key role in intestinal development and differentiation in normal and cancer tissues, and it is important for the maintenance of intestinal epithelium cells, liver-intestine cadherin(CDHIT) as one protein has intimate correlation with invasion and metastasis of tumor, has as well as highly expresses in intestinal-mucosa. Recent studies indicate that CDX2 and CDHI7 is closely associated with tumorigenesis,differentia-tion and metastasis. They might act as a new biomarker of gastric cancer diagnosis and a new target of tumor gene therapy.
