Risk factors of BK virus infection post renal transplantation
10.3760/cma.j.issn.1000-6702.2009.12.007
- VernacularTitle:肾移植术后BK病毒感染的危险因素分析
- Author:
Yingxin FU
;
Wenli SONG
;
Chunbai MO
;
Gang FENG
;
Xuexi GUO
;
Haiming ZHANG
;
Zhenglu WANG
;
Weiping ZHENG
;
Hong ZHENG
;
Zhongyang SHEN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
BK virus;
Risk factors
- From:
Chinese Journal of Urology
2009;30(12):809-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of BKV infection and compare the real-time PCR procedure and urinary sediment smears of patients checked for decoy cells. Methods The peripheral blood samples of 129 renal recipients were collected. According to the result of PCR, 129 patients were divided into 2 groups:①BKV-DNA(+);②BKV-DNA(-). The sex, age, cold ischemia time, hemotodialysis duration, immunosuppressive agent and other clinical parameters were compared between the 2 groups and a Logistic regression was performed to analyze the risk factors of BKV infection. Results There were 20(15. 5%) patients in BKV-DNA(+), 109(84. 5%)patients in BKV-DNA(-)group. Logistic regression found that the cold ischemia time, hematodialysis duration, living donor were significantly related to the BKV-DNA. The results of the real-time PCR procedure and urinary sediment smears of patients checked for decoy cells were related. Conclusion Real-time fluorescent quantitative PCR and urine decoy cell are good way for detection of BKV infection after renal transplantation. The cold ischemia time and hematodialysis duration and brain death donor were the risk factors of BKV infection post renal transplantation.
