Relationship between delayed graft function and glutathione S-transferase polymorphisms

VernacularTitle:移植肾功能延迟恢复与供者谷胱甘肽硫转移酶多态性的研究
Author: Ziqiang XU ; Jinjun WANG ; Xiaojie NI ; Bicheng CHEN ; Yirong YANG ; Shaoling ZHENG ; Jianjian ZHENG ; Yan CHEN
Publication Type:Journal Article
Keywords: Kidney transplantation; Delayed graft function; Glutathione S-transferase
From: Chinese Journal of Urology 2009;30(12):816-819
CountryChina
Language:Chinese
Abstract: Objective To explore the factors related to the delayed graft function (DGF). Methods Clinical data of 150 recipients were collected and performed by Cox proportional hazards regression analysis . In addition, the glutathione S-transferase (GST) gene polymorphism of 172 donors and 157 healthy persons was analyzed by multiple PCR and SSP-PCR. Results DGF was observed in 24 patients among 150 recipients. Pretranplantation dialysis mode, PR A levels and recipient gender were uncorrelated with the incidence of DGF(P>0. 05). Urinary volume of the second 24 hours after transplantation was an independent predictor of DGF(RR=1. 002, P = 0. 001). The frequency of donor's null GSTM1 in DGF group was significantly higher than that in non-DGF group(P<0. 05). Conclusions Urinary volume of the second 24 hours after transplantation could be a predictor for DGF. The null GSTM1 in donor might be one of the factors related to the EGF.