HIF-1α and malignant tumors of digestive system
10.3760/cma.j.jssn.1673-422X.2009.11.021
- VernacularTitle:缺氧诱导因子-1α与消化系统恶性肿瘤
- Author:
Ying GUO
- Publication Type:Journal Article
- Keywords:
Digestive system neoplasms;
Hypoxia inducible factor
- From:
Journal of International Oncology
2009;36(11):861-864
- CountryChina
- Language:Chinese
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Abstract:
Hie expression of hypoxia-inducible factor- 1a ( HIF-1a) is one of the important factors that cause most solid tumors rapid growth in hypoxic microenvironment, HIF-1a plays an important role in tumor angjogenesis, cell proliferation, metastasis and apoptosis. Similarly, HIF-1a also plays important biological roles in the occurrence and progression of digestive system carcinomas, such as esophagus cancer, stomach cancer, colon cancer, liver cancer and pancreatic cancer. HIF-1a can be used as one of the important molecular markers in prevention and treatment of gastrointestinal cancers.
