Motor function changes of sphincter of Oddi in rabbits with hypercholesteremia

VernacularTitle:高胆固醇血症对家兔Oddi括约肌功能的影响
Author: Xiaojun WANG ; Jing CUI ; Hucheng LI ; Fei CHEN ; Zhihua LI ; Xiaowu LI ; Jiahong DONG
Publication Type:Journal Article
Keywords: Hypercholesteremia; Sphincter of Oddi; Biliary manometry; Myoelectric activity
From: Chinese Journal of Digestive Surgery 2009;8(6):460-462
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of hypercholesteremia on the motor function of sphincter of Oddi (SO). Methods Thirty-two rabbits were divided into control group and experimental groups. In the control group, the rabbits were fed with normal diet. In the experimental groups, the rabbits were fed with normal diet + cholesterol for 4, 6 and 10 weeks. Myoelectric activity and pressures of SO were detected. All data were analyzed by t test. Results The serum total cholesterol and low density lipoprotein cholesterol were at a high level in rabbits which were fed with normal diet + cholesterol for 10 weeks (t=9.63, 11.38, P <0.05); basal pressure, pike pressure and amplitude of SO were significantly elevated (t=5.23, 6.34, 3.24, P < 0.05) ; the spike potential of SO changed to myoelectronic activity, with prolonged time period of myoelectronic activity, while the discharge rate was decreased (t=13.68, 10.18, P < 0.05). Conclusion Hypercholesteremia may change the motor function of SO and enhance its peristalsis to speed up the excretion of bile.