The suppressing effect of Shenkang 2 on HPA axis of rats model

VernacularTitle:肾康2号对HPA轴抑制模型大鼠的HPA轴影响的实验研究
Author: Qiongxian WEN ; Yanqiang CHEN ; Lin YE
Publication Type:Journal Article
Keywords: Shenkang 2; Hypothalamus-pituitary-adrenal axis; Adrenocorticotropic hormone; Cortisol
From: Chinese Journal of Practical Nursing 2009;25(34):12-13
CountryChina
Language:Chinese
Abstract: Objective To observe the inhibition effect of Shenkang 2 on rats'HPA axis,and provide theoretical basis for clinical application of steroid withdrawal and maintenance in the treatment phase.Methods To built the HPA axis suppression rat model by using high-dose glucocorticoids,when the hormone reduced to low-dose,traditional Chinese medicine Shenkang 2 were administrated.Serum ACTH,cortisol levels,adrenal index,adrenal pathological differences were observed before and after the treatment of Shenkang 2 among the treatment group,hormone control group and normal group.Results Serum ACTH,cortisol and adrenal index slowly recovered after hormone withdrawal in beth treatment group and the hormone control group,serum ACTH,cortisol and adrenal index in the treatment group rebounded faster than that in the control group,the atrophy of fascicular zone of adrenal cortex and cell disarrangement was lighter in the treatment group than that in the control group.Conclusions Shenkang 2 can improve the suppression effect of glucocorticoid-induced HPA axis suppression.