Clinical features of six sporadic cases of infant pulmonary hemorrhage of enterovirns 71 infection without skin rash
10.3760/cma.j.issn.1000-6680.2009.12.010
- VernacularTitle:散发6例婴幼儿无皮疹型肠道病毒71型感染致肺出血的临床特征
- Author:
Shijun HE
;
Airong HUANG
;
Yimei JIN
;
Dong CHEN
;
Haomei YANG
;
Chuanxia WANG
;
Aihua ZHOU
;
Xia WANG
;
Miaomiao LIN
- Publication Type:Journal Article
- Keywords:
Lung diseases;
Hemorrhage;
Enterovirus A;
human
- From:
Chinese Journal of Infectious Diseases
2009;27(12):749-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the clinical features of infant pulmonary hemorrhage of enterovirus 71 infection without skin rash, and to improve the diagnosis and treatment of this disease.Methods Six infants infected with enterovirus 71 and presented pulmonary hemorrhage but no skin rash between November 2007 and October 2008 were retrospectively reviewed. The clinical manifestations, clinical outcomes, treatments, laboratory data and chest imaging changes of the cases were analyzed. Results The 6 cases were all younger than 2 years old. The cases distributed throughout the whole year without peak season. Enterovirus 71 gene was detected by reverse transcription-polymerase chain reaction (RT-PCR) and real time polymerase chain reaction from throat swabs and secretions of the respiratory tract. All the cases began with fever, and 4 of which were accompanied with vomit, and 2 accompanied with cough. After 1 to 3 days, they all got sudden deterioration, manifested with pale and cyanosis, and 1 had hyperspasmia. After intubation, they all had pink frothy fluid from the endotracheal tube. They all had obvious hyperglycaemia, 4 had tachycardia, and 2 had hypertension. All the 6 cases died, and 4 died within 6 h after deterioration. Conclusions Pulmonary hemorrhage of enterovirus 71 infection without skin rash is seen in infants. It is sporadic throughout the whole year. The disease is fulminant and the case often dies in short period of time.
