The ethology representation of the modified three-vessel-occlusion rat model of chronic cerebral hypoperfusion
10.3760/cma.j.issn.1674-6554.2009.11.003
- VernacularTitle:改良型三血管结扎慢性脑缺血模型大鼠的行为学评价
- Author:
Hui LIU
;
Junjian ZHANG
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Chronic cerebral hypoperfusion;
Rat model;
Spatial learning ability;
Exploring ability;
Depression
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2009;18(11):966-969
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the ethology representation of the modified model of chronic cerebral hypoperfusion ( m-3VO) , created by occluding bolh common carotid in combination with one vertebral artey. Methods Rats were randomly put into m-3VO group,2VO group,and sham group ,and were subjected to the matching operation. Eight weeks after the operation, Morris water maze,open field test,and forced swimming lest were carried out. Results Compared with the sham group[ (18.46 ± 2. 63)s, (15. 9 ± 2. 16)s] .escape latencies of Morris water maze of m-3VO group [ ( 37. 69 ± 5. 11 ) s, ( 32. 55 ± 4. 28 ) s] and 2V0 group [ (42. 94 ± 3.05)s, (37.43 ± 4. 55)s] in the fourth and fifth days significantly increased (t = 3. 61 , P<0. 01 ; l = 3. 028, P<0.05 ; t = 4.72, P< 0. 001 ; t = 4. 153, P<0.001). The time of m-3VO group[ (7. 72 ± 1. 92) s] and 2VO group[ (7. 154 ± 2.66)s] spent in NE square was also longer than that of the sham group[(11. 19 ± 2. 137)s] (q = 2.98, P< 0.05; q = 3.81 , P< 0.01 ). And the crossing score of open field test of 2VO group(83. 25 ± 13. 53) was higher than that of the sham group (55. 6 ± 16. 8) ( q = 3. 27, P < 0. 01 ) , but immobility times, swimming times and climbing times of forced swimming test were not different between the three groups (P>0. 05). Conclusion The spatial learning ability of m-3V0 group rats are impaired 8 weeks after the operation, which is similar to that of 2VO group rats,and the m-3V0 operation have few effect on exploring ability and depression of rats.
