Postoperative recurrence of liver malignant tumor after liver transplantation
10.3760/cma.j.issn.1007-631X.2009.12.010
- VernacularTitle:肝脏恶性肿瘤肝移植术后肿瘤复发的临床研究
- Author:
Lei HUANG
;
Jiye ZHU
;
Guangming LI
;
Tao LI
;
Pengji GAO
;
Xisheng LENG
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Liver transplantation;
Neoplasm recurrence,local
- From:
Chinese Journal of General Surgery
2009;24(12):984-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical characteristics of postoperative recurrence of liver malignant tumor after liver transplantation,the postoperative standard evaluation,and treatment for recurrent tumor. Methods We retrospectively analyzed the data of 81 recurrent cases among 215 patients undergoing liver transplantation for malignant liver tumors,focusing on the recurrent time and location and the result oftreatment.Results The follow-up time ranged from 6 to 108 months of all the 81 patients after liver transplantation.The time of tumor recurrence ranged from 3 to 20 months after transplantation.and lung,abdominal cavity,new liver and bone were among the most common places of recurrence.Local therapy was the mainstay of therapy,including liver lobectomy in 6 cases and gamma knife treatment for pulmonary metastasis in 74 cases;Resection for abdominal mass Was performed in 10 cases.Gamma knife treatment for abdominal lymph node metastasis in 8 eases,resection of hepatic metastatic tumor in 6 cases,ablation therapy in 5 cases,gamma knife treatment in 15 cases,33 cases underwent repeated TACE and 3 cases received re-transplantation for liver metastasis;For bone metastasis 15 cages underwent resection,16 cases did gamma knife treatment and 3 cases underwent internal fixation for bone fracture caused by bone metastasis;For intracranial metastasis 4 cnses received gamma knife treatment.3 cases were cured,6 cases were still alive with recurrent tumor for 21～56 months respectively and the mean survival time was 39 months;72 cnses died with a mean survival time of 15 months.Conclusion The regular and standard close follow-up for liver transplantation recipients suffering from primary liver malignant tumors and aggressive therapy for the recurrent tumors help prolong patient's survival.
