Analysis of 27 cases with lamivudine-resistant mutation associated chronic severe hepatitis B
10.3760/cma.j.issn.1000-6680.2009.06.007
- VernacularTitle:拉米夫定耐药突变相关慢性重型乙型肝炎27例分析
- Author:
Ruiying ZHENG
;
Mobin WAN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Variation(genetics);
Lamivudine,Hepatitis B,chronic Oligonucleotide array sequence analysis
- From:
Chinese Journal of Infectious Diseases
2009;27(6):348-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of lamivudine-resistant mutation associated chronic severe hepatitis B during lamivudine treatment.Methods Twenty-seven patients with lamivudine-resistant mutation associated chronic severe hepatitis B during lamivudine treatment were analyzed retrospectively.YMDD motif mutation was detected by gene chips or DNA sequencing.The pathological features of liver tissues from 8 patients undergoing liver transplantation were analyzed.The X2 test were used to perform the stafistical analysis.Results The YMDD motif mutations of 27 lamivudine-resistant patients were 5 cases of YVDD mutation,2 of YVDD+L180M,13 of YIDD mutation,4 of YIDD+L180M,1 of YVDD+YIDD mutations,2 of YVDD+YIDD+L180M,and there was no single L180 M mutation among patients.Twenty-seven patients were divided into cirrhotic group and noncirrhotic group according to whether they were diagnosed with cirrhosis before treatment.Compared to cirrhotic group,incidence of severe hepatitis was lower,prognosis was better,the age of patients was younger and hepatitis Be antigen(HBeAg)positive rate was higher in noncirrhotic group.There were two types of pathological features of liver tissues from 8 patients,which were active hepatic cirrhosis and massive or submassive hepatic necrosis with liver shrinking significantly.Conclusions Hepatic cirrhosis is a risk factor of lamivudine-resistant mutation associated chronic severe hepatitis B.There may be two mechanisms in lamivudine-resistant mutation associated chronic severe hepatitis B.
