Surgery for hepatocellular carcinoma: salvage liver transplantation versus primary liver transplantation
10.3760/cma.j.issn.0254-1785.2010.01.006
- VernacularTitle:肝切除后再行肝移植与直接行肝移植治疗肝癌的比较
- Author:
Jie CHEN
;
Yonghua XU
;
Xiangcheng LI
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Hepatectomy;
Liver transplantation;
Case-control studies
- From:
Chinese Journal of Organ Transplantation
2010;31(1):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effectiveness and advantage of salvage liver transplantation post-resection with primary liver transplantation for HCC patients. Methods Medline, Embase, Cochrane, CBMdisc, CNKI and Wanfang Database were searched. Randomized and nonrandomized controlled trials comparing primary liver transplantation with salvage liver transplantation were analyzed. Ten retrospective studies involving 1115 patients were included. 164 received salvage liver transplantation,and 951 patients received primary liver transplantation. Results In most researches, the two groups of patients were similar for age, sex,and cirrhosis severity at time of transplantation. Some researches showed no difference in tumor size and number between the two groups. Few studies referred to microvascular invasion. Most of the researches showed there was no significant difference in blood loss,operative time,overall survival and disease-free survival between the two groups. Conclusion Compared to primary liver transplantation, salvage liver transplantation after liver resection is associated with similar operative time, risks and overall survival. Resection first and salvage liver transplantation for recurrent tumors or liver failure seem to be a feasible treatment strategy for hepatocelluar carcinoma,especially in early-stage.
