Clinicopathological observation and analysis of donor liver and biopsy in liver transplantation

VernacularTitle:肝移植术供体肝脏及其肝穿活检临床病理观察分析
Author: Li LUO ; Yin CHEN ; Xiaolong JI
Publication Type:Journal Article
Keywords: Liver transplantation; Donor liveri Liver biopsy; Histopathology
From: Chinese Journal of Hepatobiliary Surgery 2009;15(12):885-887
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between histopathological changes of donor liver and those after liver transplantation and explore its effects on prognosis.Methods The histopathological changes of donor liver and post-transplantation live biopsy were observed in 87 cases.Results The percentage of hepatic degeneration at immediate biopsy of donor liver was 100%,the injury of sinusoid endothelial cell accounted for 41.3%,the hepatic steatosis for 18.3%and the necrosis of liver cells for 10.3%.Conclusion Most of the pathological changes of the donor liver during and after liver transplantation are reversible.The damage of the hepatic sinusoidal cells is the important criterion for the observation of ischemia reperfusion injury.Moderate and heavy hepatic steatosis can be used in the liver transplantation. After liver transplantation,if the necrosis of liver cells gradually gets serious,the risk of transplanted liver losing its function gets bigger,so the comparative observation has very important value in diagnosis.