Relationship between depression and the function of cognition in patients with obstructive sleep apnea-hypopnea syndrome
10.3760/cma.j.issn.1674-6554.2009.12.015
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患者抑郁情绪和认知功能损害的关系
- Author:
Shukun YANG
;
Jianwei ZHUANG
;
Xia FU
- Publication Type:Journal Article
- Keywords:
Sleep apnea;
Obstructive;
Depression;
Cognition disorders
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2009;18(12):1100-1102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the depression and cognition function in patients with severe obstructive sleep apnea (OSAHS) , and to study the relationship between the depression and severity of OSAHS, cognition disorders. Methods A total of 74 OSAHS patients (OSAHS group) and 39 normal controls ( control group) which all diagnosed by polysomnography (PSG) were chosen, and they were assessed the state of depression by self-rating depression scale ( SDS) and for cognition disorders by mini-mental state examination ( MMSE ). Results The score of SDS in OSAHS group was significantly higher than that in the control group(P<0.01). In patients with OSAHS , the score of SDS was positively correlated with apnea hyponea index ( AHI) , which was negatively correlated with mean level of SaO_2 ( MSaO_2 ) and the lowest SaO_2 ( LSaO_2 ) (P<0.01 ). The score of MMSE in OSAHS group was significantly lower than that in the control group, which was negatively correlated with AHI(P<0.01) and positively correlated with MSaO_2 and the lowest LSaO_2(P<0.01 ). The score of SDS was negatively correlated with MMSE( r= -0.505, P<0.01). Conclusion OSAHS patients exit depression and cognition disorders, which was correlation to intermitten hypoxemia in frequently.
