Effects of the combination α_2-adrenergic receptor agonist and k-opioid receptor agonist on post-resuscitation cardiac function in rabbits
10.3760/cma.j.issn.1671-0282.2009.12.017
- VernacularTitle:联用α_2-肾上腺素能受体激动剂和k-阿片受体激动剂对复苏后兔血流动力学和B型利钠肽的影响
- Author:
Qian ZHANG
;
Xiaohua YANG
;
Peijie LI
;
Huiping LI
;
Youfan FENG
;
Zonbao LIU
- Publication Type:Journal Article
- Keywords:
α_2-Adrenergic receptor;
k-Opioid receptor;
Agonist;
Ventricular fibrillation;
Cardiopulmonary resuscitation;
Post-resuscition myocardial dysfunction;
Hemodynamics;
B-type natriuretic peptide
- From:
Chinese Journal of Emergency Medicine
2009;18(12):1292-1296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of α_2-adrenergic receptor agonist and k-opioid receptor agonist jointly used on hemodynamics and B-type natriuretic peptide in rabbits,and to explore the effective methods for lessensing post-resuscitation myocardial dysfunction.Method After the establishment of cardiopulmonary resuscitation (CPR) model in rabbits, 30 rabbits were randomly divided into 5 groups, namely epinephrine group(E), vasopressin group(V), U50488H group(U), mivazerol group(M) and mivazerol + U50488H group(M + U). Hemodynamics and B-type natriuretic peptide were examined before ventricular fibrillation and in the early stage of post CPR (30-240 min). Statistical analysis was performed with ANOVA techniques. Results (1)MAP,peak - dp/dt and peak + dp/dt in M + U group were significantly higher than those in other groups, and the increase of LVEDP was less than that in other groups (P<0.05).(2)The concentration of BNP in M + U group was significantly decreased than that in other groups (P <0.01 or P <0.05). Conclusions The α_2-adrenergic receptor agonist (mivazerol) and k-opioid receptor agonist used together can improve post CPR hemodynamics and reduce the concentration of B-type natriuretic peptide, lessening the post CPR myocardial dysfunction.
