Effect of tumor necrosis factor-α and asymmetric dimethylarginine on left ventricle of patients with primary hypertension
10.3760/cma.j.issn.1008-6315.2010.01.002
- VernacularTitle:非对称性二甲基精氨酸和肿瘤坏死因子对原发性高血压左心室构型的影响
- Author:
Xin LI
;
Jiuying CAI
- Publication Type:Journal Article
- Keywords:
Primary hypertension;
Left ventricle;
Tumor necrosis factor-α;
Asymmetric dimethylarginine
- From:
Clinical Medicine of China
2010;26(1):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the level of tulnor necrosis factor-α(TNF-α)and asymmetric dimethylarginine (ADMA) in serum of healthy adults and primary hypertension patients with different left ventricle,and to explore the role of TNF-α and ADMA in the pathophysiological mechanism of heart damage due to hypertension.Methods Thirty health adults were recruited as control.Based on the left ventricular mass index(LVMI)and relative wall thickness(RWT),66 patients of hypertension were divided into 4 groups:normal left ventricle group with normal LVMI and RWT,concentric remolding group with normal LVMI and incremental RWT,typical concentric hypertrophy group with incremental LVMI and RWT,eccentric left ventricular group incremental LVMI and normal RWT.TNF-α was measured by radioimmunoassay and ADMA was measured through reversed phase high-performance liquid chromatography.Resuits TNF-α and ADMA increased with the severity of the left ventricle.Each left ventricle group was significantly higher than control group (P<0.01).The differences between left ventricle groups were statistically significant (P<0.01).Conclusions TNF-α and ADMA may participate in the development of left ventricle.
