Analysis of risk factors of various degrees of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1008-6315.2010.01.011
- VernacularTitle:2型糖尿病合并不同程度非酒精性脂肪性肝病的危险因素分析
- Author:
Manman WANG
;
Longyi ZENG
;
Jiong SHU
;
Yan SUN
;
Yanming CHEN
;
Guochao ZHANG
;
Panwei MU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Non-alcoholic fatty liver;
Dyslipidemia;
Insulin resistance
- From:
Clinical Medicine of China
2010;26(1):27-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between dyslipidemia,obesity,insulin resistance (IR)and various degrees of non.alcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus (T2DM), and the risk factors of NAFLD.Methods Two hundred and sixty-eight patients were divided into three groups(non-NAFLD group,mild NAFLD group,moderate and severe NAFLD group)by liver ultrasonography.Body height(H),weight(W),waist circumference(WC),hip circumference(H)were measured.The levels of fasting blood glucose (FBG),glycosylated hemoglobin A_1c(GHbA_1C),serum total cholesterol(TC),serunl high density lipoprotein(HDL-C),serum low density lipoprotein(LDL-C),serum triglyceride (TG),alanine aminotransferase (ALT)and fasting serum insulin(FINS)were measured.Body mass index(BMI),the waist to hip ratio(WHR)and insulin resistance index(HOMA-IR)were calculated.Unconditional logistic regression model was used to test for the risk factors of NAFLD.Results BMI、WC、WHR、HNS、HOMA.IR、TC、LDL-C、TG and ALT in NAFLD group were significantly higher than those in non-NAFLD group (P<0.05).The levels of BMI、WC、WHR、HNS、HOMA-IR、 TG and ALT increased significantly in moderate and severe NAFLD group compared with mild NAFLD group(P<0.05).TG、WHR and HOMA.IR were the risk factors of NAFLD(P<0.05,OR=2.394,3.273,5.256).Conclusions NAFLD in patients with T2DM had remarkable dyslipidemia,overweight,central obesity and insulin resistance.TG、WHR and HOMA.IR were risk factors of NAFLD.
