Clinical analysis of caspofungin treatment for invasive fungal disease in advanced age patients

VernacularTitle:卡泊芬净治疗高龄患者侵袭性真菌病29例临床分析
Author: Yanping ZHU ; Lin SHAN ; Yinan ZHOU ; Xiangyang LI ; Huili ZHU
Publication Type:Journal Article
Keywords: Antifungal agents; Mycoses
From: Chinese Journal of Geriatrics 2010;29(1):17-19
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy and safety of caspofungin in the treatment of invasive fungal disease (IFD) in advanced age patients. Methods A retrospective analysis of the clinical data was conducted. IFD patients who had received caspofungin treatment in elderly wards were included. Results From January 2007 to August 2009, 29 IFD patients aged 80-100 years (mean 89 ) were treated with caspofungin. Except that one patient dead on the first drug administration day, there were 28 evaluable patients, 13 were cured (46.4%), 6 were markedly improved (21.4%), 3 progressed (10.8%) and 6 dead (21.4%). The overall effective rate was 67. 8%. Of 13cured patients, 12 were Candida bacreremia, 1 was Candida albicans disease of lung. Of 6 dead patients, 2 were Candida bacteremia, 1 was Candida albicans disease of lung and 3 was suspected of lung IFD. One patient performed that alanine aminotransferase was increased, considering drug-related impairment of liver function. Conclusions Caspofungin is effective and safe in the treatment of IFD in advanced age patients.