Efficacy of domestic low-dose clopidogrel for patients with unstable angina pectoris

VernacularTitle:低剂量氯吡格雷治疗不稳定心绞痛疗效观察
Author: Yuchen LI ; Yingqing CHEN
Publication Type:Journal Article
Keywords: Angina; unstable; Platelet aggregation
From: Chinese Journal of Geriatrics 2010;29(1):33-34
CountryChina
Language:Chinese
Abstract: Objective To compare the efficacy of domestic low-dose versus conventional-dose clopidogrel for patients with unstable angina pectoris (UAP). Methods A total of 206 UAP patients were randomly assigned to low-dose clopidogrel (50 mg/day) as treatment group and conventional-dose clopidogrel (75 mg/day) as control group. Treatment continued for 12 months to observe the extent of alleviating angina and major adverse cardiac events (MACE). Results The numbers of markedly effective, effective, ineffective and worse patients were 56(52.8%), 22 (20.8%), 11(10.4%) and 17(16.0%) in treatment group, and those were 52(51.0%), 20 (19.6%), 12(11.8%) and 18(17.7%) in control group (all P>0. 05). There was death in 3 cases, non-fatal myocardial infarction in 2 cases in treatment group, and death in 4 cases, non-fatal myocardial infarction in 2 cases in control group (χ~2 =0. 620, P>0. 05). Low-dose group had a lower incidence of adverse reactions. Conclusions The efficacy of low-dose clopidogrel for patients with UAP is not inferior to conventional-dose, and the safety is well.