The clinical value of measurement of urine nuclear matrix protein 22 and urinary bladder cancer antigen content in patients of bladder transitional cell carcinoma
10.3760/cma.j.issn.1008-6315.2010.01.035
- VernacularTitle:核基质蛋白22及尿膀胱癌抗原在膀胱移行细胞癌诊断中的价值
- Author:
Yunfei LIU
;
Jiang ZHENG
;
Changmao LIU
;
An XIA
;
Haitao DAI
- Publication Type:Journal Article
- Keywords:
Bladder transitional cell carcinoma;
Nuclear matrix protein 22;
Cytokeratins;
Urinary bladder cancer antigen
- From:
Clinical Medicine of China
2010;26(1):80-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the feasibility of nuclear matrix protein 22(NMP22)and urinary bladder cancer,antigen (UBC) for the early diagnosis of bladder transitional cell carcinoma and its influencing factors.Methotis 105 subjects,including 60 patients of bladder cancer,25 patients of urological benign disease and 20 normal (healthy)individuals were enrolled in this study.Urine NMP22 and UBC wag assessed by enzyme-linked immunosorbent assay(ELISA).Urine NMP22 and UBC as well as exfoliocytology were conducted for the purpose to compare the sensitivity,specificity,positive and negative predictive value of these three ways.Results The sensitivity of NMP22(88.3%)and UBC(86.7%)were significantly better than exfolioeytology(40.0%,P<0.01).The specificity of NMP22,UBC and exfoliocytology were 80.0%,84.0%and 92.0%,respectively, the positive predictive values were 91.4%,92.9%and 92.3%,and the negative predictive values were 74.1%.72.4%and 38.9%.Conclusions NMP22 and UBC are sensitive,specific,simple,feasible and noninvasive diagnostic markers for the early detection of urinary bladder transitional cell cancer.
