Application of Phadiatop UniCAP in detection in children with allergic diseases
10.3760/cma.j.issn.1008-6315.2010.01.044
- VernacularTitle:CAP检测系统在儿童变态反应性及免疫性疾病的应用
- Author:
Junhong ZHANG
;
Shuying BI
;
Hua XU
- Publication Type:Journal Article
- Keywords:
Eosinophil cationic protein;
Atopic dermatitis;
Asthma;
Allergic purpum;
Kawasaki disease
- From:
Clinical Medicine of China
2010;26(1):100-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate a blood test,UniCAP system(screening IgE to food or inhalant allergens,eosinophil cationic protein,ECP)in differentiation the capability of lgE-mediated allergic diseases in children. Methods 26 atopic dermatitis,33 asthma/bronchiolitis,20 allergic purpura, 15 Kawasaki disease patients and 20 normal children were tested total lgE,lgE to food or inhalant allergens,ECP by UniCAP system and compared.Resuits Fx5E positive rate are 73.1%,24.2%,25.0%,13.3%in atopic dermatitis,asthma,allergic purpura,Kawasaki disease respectively,and the Phadiatop positive rate are 23.1%、69.7%、10.0%、6.6%.The serum levels of ECP、TIgE of patients were higher than the mormal controls,with the highest level in asthma, and lowest in Kawasaki disease,the differences were significant(P<0.05).Conclusions Food orinhalant allergens plays an important role in the inflammatory process of asthma,atopic dermatitis,and some role in allergic purpura,Kawasaki disease.Food allergens are more important to atopic dermatitis.and inhalant allergens are more important to asthma.
