Effects of MIF on expression of the collagen Ⅰ and Ⅲ protein in SMC
- VernacularTitle:MIF对大鼠动脉平滑肌细胞合成Ⅰ、Ⅲ型胶原蛋白的影响
- Author:
Jun LI
;
Ling ZHANG
;
Xinli PANG
;
Lingjie LUO
- Publication Type:Journal Article
- Keywords:
Macrophage migration-inhibitory factors/PD;
Collagen type Ⅰ/ME/DE;
Collagen type Ⅲ/ME/DE;
Myocytes,smooth muscle/ME/DE
- From:
Journal of Chinese Physician
2009;11(12):1605-1607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of MIF stimulation on collagen Ⅰ and Ⅲ synthesis in the cultured blood vessel SMC ofrats. Method The content of collagen Ⅰ and Ⅲ protein in primary culture of SMC was measured with Western-blot. Results MIF couldpromote the increasing of the collagen Ⅰ protein expression in the SMC. But there were no improvement on collagen Ⅲ. Conclusions MIFcould stimulate SMC to synthesize the collagen Ⅰ.
