Effects of erythropoietin on expressions of myocardial cell Bcl-2 and Bax in rats with acute myocardial infarction
10.3760/cma.j.issn.1008-6706.2009.11.006
- VernacularTitle:促红细胞生成素对大鼠急性心肌梗死心肌细胞Bcl-2、Bax表达的影响
- Author:
Shuai QI
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Acute myocardial infarction;
Apoptosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(11):1930-1931
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of erythropoietin on expressions of myocardial cell Bcl-2 and Bax in rats with acute myocardial infarction(AMI).Methods Rats that survived after AMI were randomly divided into treatment group and control group. Treatment group were given EPO 3000 U/kg, A total of 3 d(preoperative 1 day, the same day, after 1 day),control group at the same point in time given the same amount of saline by the intraperitonealy injection. After 4 weeks, hemodynamics and left ventricular function were measured with catheterization,Bcl-2 and Bax were analyzed by immunohistochemical method. Results After 4 weeks, LVSP and +dp/dt_(max) in treatment group were significantly higher than those in control group(P＜0.05),LVEDP and-dp/dt_(max) were significantly lower than those in control group(P＜0.05);Change of heart rate in two groups were no difference(P＞0.05).The expression of myocardial cell Bcl-2 in treatment group were significantly higher than that in control group(P＜0.05);the expression of myocardial cell Bax and Bcl-2/Bax in treatment group were significantly lower than that in control group(P＜0.05).Conclusion The protective effect of EPO on ischemia and infarction of cardiac function may be related to the reduction of cardiomyocyte apoptosis.
