Effect of curcumin on the expression of C-erbB-2, Survivin and Bax in prostatic cancer cell (DU145)
- VernacularTitle:姜黄素对前列腺癌细胞C-erbB-2,Bax和Survivin表达的影响
- Author:
Zhenshan XIA
;
Aihua BO
- Publication Type:Journal Article
- Keywords:
Curcumin/PD;
Prostatic neoplasms/ME;
Receptor,erbB-2/ME;
Proto-oncogene proteins/ME;
Microtubule-associated proteins/ME
- From:
Journal of Chinese Physician
2009;11(12):1623-1625
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of curcumin on the expression of C-erbB-2, Survivin and Bax in prost cancer cell. Methods The effects of curcumin on the expression of C-erbB-2, Suevivin and Bax were observed by SP immnohistocherminstry and cell cultivate methods. Results The expression of Survivin and C-erbB-2 in contrast group were strong, but the expression of Bax was very weak. After the curcumin were incubated with culture medium for 6h, 12h, 24h, 48h, the expression of C-erbB-2 and Survivin were gradually decreased in DU145 cells, while the expression of Bax was increased and reached highest at the time point of 12 ～24h. Conclusion The curcumin can reduce the expression of C-erbB-2 and surviving, and increase expression of Bax. The curcumin may exert antitumor activity by interacting with DU145 cells.
