Detection of serum HE4 and CA125 in patients with ovarian cancer and its clinical significance

VernacularTitle:卵巢癌患者血清人附睾分泌蛋白4和CA125的检测及其诊断意义
Author: Feng WANG ; Yumei LIAO ; Wuliang WANG ; Dongmei HUANG
Publication Type:Journal Article
Keywords: Ovarian cancer; Human epididymis protein 4; CA125
From: Clinical Medicine of China 2010;26(1):92-94
CountryChina
Language:Chinese
Abstract: Objective To investigate the significance of haman epididymis protein 4(HE4)as a tumor marker combined with CA125 in diagnosis of epithelial ovarian cancer.Methods Serum levels of HE4 and CA125 were examined by ELISA and electrochemiluminescence method in 31 patients with ovarian cancer,68 patients with benign pelvic masses(36 benign ovarian tumor,23 ovarian chocolate cyst and 9 pelvic abscess were included) and 40 normal women as controls.Results Serum levels of HE4 and CA125 in ovarian carcinoma group were significantly higher than those in the benign pelvic masses group and healthy women group(P<0.01), and the difference of these levels between benign pelvic masses and normal ones have no statistical meaning(P>0.05).The sensitivity and the specificity of HFA were 74.2% and 95.0% respectively,of CA125,were 80.6% and 87.5%.respectively,and if the two markers combined,were 93.5% and 82.5%.Conclusions HFA is an ideal tumor marker and it has certain values in accessory diagnosis and differential diagnosis of ovarian cancer.The clinical value call be improved by combined detection of HE4 and CA125.