Roles of calreticulin on anti-tumor effection
10.3760/cma.j.issn.1673-422X.2009.12.007
- VernacularTitle:钙网蛋白的抗肿瘤作用
- Author:
Yan WU
;
Jinwen HUANG
- Publication Type:Journal Article
- Keywords:
Calreticulin;
Neoplasms;
Immunogenicity
- From:
Journal of International Oncology
2009;36(12):900-902
- CountryChina
- Language:Chinese
-
Abstract:
Calreticulin (CRT) participates in the progression and apoptosis of many kinds of tumor cells. Recent studies indicate expression of CRT on tumor cells acts as an "eat me" signal for dendritic cells,allowing them to phagocytose tumor cells. It can induce immunogenic tumor cell death by adsorbing recombinant calreticulin to tumor cells or by enforcing the translocation of endogenous calreticulin to the cell surface. In animal experiments,CRT related tumor vaccine has good therapeutic effects in some tumor bearing mice,which can be used in tumor immunotherapy and targeted therapy.
