Relationship between the mutation of the exon 4 of leptin receptor gene and left ventrtcular function and renal hemodynamics in patients with hypertension
10.3760/cma.j.issn.1673-4904.2010.01.005
- VernacularTitle:高血压患者左心室功能及肾脏血流动力学与瘦素受体基因外显子4Lys109Arg变异的关系
- Author:
Nan WANG
;
Bei CHENG
;
Liya MA
- Publication Type:Journal Article
- Keywords:
Hypertension;
Ventricular function,left;
Renal hemodynamics;
Leptin receptor gene
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the mutation of the exon 4 of leptin receptor gene(4Lys 109 Arg)and left ventricular function and renal hemodynamics in patients with hypertension.Methods From December 2005 to December 2006,digoxin marked primer enzyme coloration technique was used to detect the 4Lys 109 Arg polymorphism.The color Doppler echocardiography was used to detect the left ventricular function and the renal hemodynamics.The study covered 90 patients with hypertension (hypertension group)and 52 controls (control group).Results The frequencies of 4Lys109Arg in hypertension group and control group had no significant difference.The hypertension with GG genotype was significant difference in left ventrieular ejection fraction(LVEF),E/A,left ventrieular fractional shortening(LVFS),resistance index(BI),pulsatility index(PI)(P<0.05).The hypertension with GA genotype had significant difference in LVEF,E/A,LVFS(P<0.05).In hypertension group,LVEF,E/A,LVFS.RI and PI had significant difference between GG and AA genotype(P<0.05).In control goup,RI had significant difference between GG and AA genotype(0.65 ±0.02 vs 0.63±0.02,P<0.05).Conclusion The renal hemodynamics and the left ventricular function are associated with 4Lys109Arg polymorphism.
