Effects of fasudil hydrochloride injections on endothelin-1 and nitric oxide contents in plasma and cerebrospinal fluid after subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4904.2010.01.008
- VernacularTitle:盐酸法舒地尔对蛛网膜下隙出血后血浆和脑脊液中内皮素-1和一氧化氮水平的影响
- Author:
Yongjun CHEN
;
Xinhua ZHANG
;
Wei ZOU
;
Shuyun LIU
;
Fusheng JIANG
- Publication Type:Journal Article
- Keywords:
Subarachnoid;
Vasospasm,intracranial;
Endothelin-1;
Nitric oxide;
Fasudil
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of fasudil hydrochloride injections on the levels of endothdin(ET)-1,nitric oxide(NO)in plasma and cerebrospinal fluid(CSF)in patients with subarachnoid hemorrhage(SAH),and analyze,its mechanisms in preventing cerebral vasospasm(CVS).Method Sixty SAH cases were randomly divided into fasudil group(30 cases)and control group(30 cases).On 2nd and 10th day after in hospital,the speed of cerebral blood flow was measured by transeranial Doppier(TCD),and the levels of ET-1,NO in plasma and CSF were measured by radio-immunity.Results The incidence of CVS in fasudil group were significantly less than those in control group[6.67%(2/30)vs 36.67%(11/30),P<0.05].On the 10th day,the levels of ET-1 in plasma and CSF in fasudil group were signitlcandy lower than those in control group[(118.23±14.56)ng/L vs(132.26±15.18)ng/L,(138.23±16.58)ng/L vs (156.24±17.54)ng/L ](P<0.05),the levels of NO were significantly higher than those in control group [(88.25±15.54)μmol/L vs(70.26±14.86)μmol/L,(104.27±16.52)μmol/L vs(92.43 ±12.51)±mol/L](P<0.05).But there were no significant difference on the 2nd day(P>0.05).Conclusion Fasudil can reduce CVS in patients with SAH by lowering the levels of ET-1 and increasing the levels of NO in plasma and CSF.
