The effects of folk acid and B vitamins supplement on vascular endothelial function in patients of coronary artery disease who undergone interventional therapy
10.3760/cma.j.issn.1673-4904.2010.01.013
- VernacularTitle:补充叶酸及B族维生素对冠心病患者介入治疗后血管内皮功能的影响
- Author:
Xiaojie WU
;
Caijie LI
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Endothelium,vascular;
Vitamin B,complex;
Folic acid
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the improvement of endothelial function by folic acid and B vitamins supplement in patients of coronary artery disease who undergone interventional therapy.Methods Eighty patients of coronary artery disease who undergone interventional therapy were divided into two groups:control group(40 cases,routine treatment)and treatment group(the others,with routine treatment plus orally taken folic acid and B vitamins,folic acid 15mg/d,vitamin B_(12)75μg/d,vitamin B_6 30mg/d,for 6 months).Plasma homocystine (Hcy)was measured by fluorescence polarization immunoassay and flow-mediated dilation(FMD)of the brachial artery was assessed by high resolution ultrasound before and after 6 months.Results After treatment,the levels of Hcy decreased obviously in treatment group[(8.62±3.51)μmol/L]than that in control group[(12.96±4.62)μmol/L](P<0.01).The FMD was increased significantly in treatment group[(4.22±1.46)%vs (8.74±1.51)%,P<0.01].Conclusions Routine treatment,including aspirin and stafins,significantly improves endothehal function in patients with coronary artery disease.Folic acid and B vitamins supplement may exert beneficial effects on patients with coronary artery disease.
