Effects of Aprotinin on the levels of cerebral IL-1β,IL-6 and IL-8 in rats experienced focal cerebral ischemia reperfusion

VernacularTitle:抑肽酶对大鼠局灶性脑缺血再灌注后白细胞介素-1β、白细胞介素-6和白细胞介素-8的影响
Author: Chengping JIANG ; Bihua WU ; Xiaoming WANG
Publication Type:Journal Article
Keywords: Aprotinin; Cerebral ischemia-reperfusion injury; IL-1β; IL-6; IL-8; Rats
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(11):1928-1929
CountryChina
Language:Chinese
Abstract: Objective To observe the protective effect of aprotinin on the cerebral ischemia-reperfusion injury. Methods Rat model of cerebral ischemia-reperfusion injury was created by the middle cerebral artery embolization. The changes of IL-1β,IL-6 and IL-8 content in the brain tissue were measured by ELISA. The neurological scores were made on Zea Longa 5-point scale. Results In model group, the IL-1β,IL-6 and IL-8 protein content began to increase slightly at 3 hours compared with sham group, reached the peal[at 12 hours. In the aprotinin treated group, aprotinin reduced the protein content. It showed no significant difference between model group and aprotinin treated group at 3 hours, however and there was greatly difference at 6,12 and 24 hours between these two groups. Conclusion The present study provides in vivo evidence that aprotinin protects brain against cerebral ischemia-reperfusion injury. The mechanism is related to the decrease of cerebral levels of IL-1β,IL-6 and IL-8.