Correction between cytokine expressions in circulating CD4~+ CD28~-T cells and Graves'ophthalmopathy
10.3760/cma.j.issn.1000-6699.2010.01.011
- VernacularTitle:外周血CD4~+CD28~-T细胞表达的细胞因子与Graves眼病的相关性
- Author:
Zhiping SUN
;
Weixue ZHONG
;
Heng MIAO
;
Gehua YU
;
Na YOU
;
Xueguang ZHANG
- Publication Type:Journal Article
- Keywords:
Graves'ophthalmopathy;
T cell;
Cytokines
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(1):39-40
- CountryChina
- Language:Chinese
-
Abstract:
The immune effect of CD4~+CD28~-T cells on Graves'ophthalmopathy(GO)was investigated.The expressions of interferon-γ(IFN-γ),interleukin-2(IL-2),and IL-4 in CD4~+ CD28~-T ceils were assayed by flow cytometry in GO patients,Graves'disease(GD)patients without ophthalmopathy,and healthy control subjects.The results showed that the percentage of CD4~+CD28~-T cells significantly increased in GO patients(P<0.05),with increased IFN-γ expression(P<0.05)and decreased IL-2 expression(P<0.05).These changes were closely correlated with clinical activity score(P<0.05).There were no significant differences in IL-4 expression among three groups.The resuh suggests that CIM~+ CD28~- T cells which hishly secrete IFN-γare related to the pathological lesion of GO.
